EFFECT OF DIETHYLSTILBESTROL ON CELL-KINETICS OF SUBCUTANEOUS GROWTH OF DIETHYLSTILBESTROL-INDUCED RENAL CARCINOMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (3) , 315-320
Abstract
A response to diethylstilbestrol (DES) of DES induced renal carcinoma in Syrian hamsters was studied by comparing subcutaneous growth of this tumor in DES treated and untreated animals with respect to the growth curve, cell cycle time, Tc, growth fraction, GF and cell loss factor, .vphi.. In both conditions tumor growth followed the Gompertz curve, but the latent period was 14 days longer without DES than with DES. In untreated animals Tc was 80% longer due to increases of TGl and TS, but .vphi. was not changed significantly and GF increased without DES. DES dependency of this tumor growth was manifested in the prolongation of Tc.