DELAYED-HYPERSENSITIVITY RESPONSES TO HUMAN-IGG AND METHYLATED BOVINE SERUM-ALBUMIN ARE REGULATED BY DIFFERENT MECHANISMS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (1) , 19-29
Abstract
Marked differences in in vitro and in vivo delayed hypersensitivity (DH) responses to human IgG (human .gamma.-globulin, HGG) and methylated bovine serum albumin (MeBSA) were found. Lymph node cells (LNC) from cyclophosphamide (CY) pretreated, antigen-adjuvant immunized mice exhibited increased HGG-induced and decreased MeBSA-induced proliferative responses in vitro compared with LNC from similarly immunized by non-CY pretreated animals. These effects were antigen-specific. Treatment of Cy-HGG-adjuvant immunized mice with aqueous (aq) HCC, either before or after immunization markedly suppressed HGG-specific in vitro proliferation and in vivo DH responses. Induction of suppression by aqHGG did not appear to depend on Cy-sensitive cells either as a possible source of suppressor cell precursors or as participants in the regulatory events. In vivo DH reactivity to MeBSA was unaffected by administration of aqMeBSA either before or after mice were immunized with Cy-MeBSA-adjuvant. DH response to HGG and MeBSA may be regulated by distinct mechanisms which influence the induction and the development of sensitivity.

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