THE GUANIDINE BASES IN THE BLOOD OF DOGS WITH EXPERIMENTAL HYPERTENSION PRODUCED BY CONSTRICTION OF THE RENAL ARTERIES

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Abstract
Studies were made to determine whether the guanidine bases bore any relationship to this type of elevated blood pressure. The expts. indicated that the rise in these substances, as detd. colorimetrically on peripheral blood, paralleled the N retention rather than the rise in blood pressure occasioned by constriction of the renal artery. In an effort to further control these expts., the level of these substances was detd. in the blood of bilaterally nephrectomized dogs. These animals failed to evidence any rise in blood pressure and the guanidine base values rose in proportion to the N retention. These substances are evidently not concerned in the etiology of this type of exptl. hypertension.

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