AN IMMUNOSUPPRESSIVE FACTOR IN THE SERUM OF BABOONS (PAPIO-ANUBIS) INFECTED WITH SCHISTOSOMA-MANSONI
- 1 January 1980
- journal article
- research article
- Vol. 39 (4) , 589-598
Abstract
Serum taken from baboons infected with S. mansoni suppressed in vitro reactivity of normal baboon lymphocytes. The concanavalin A response was significantly suppressed by such serum, whereas the specific suppression of the phytohemagglutinin response was minimal. Serum from S. mansoni-infected donors depressed the mixed lymphocyte reactions to xenogeneic targets but did not affect the specific transformation of lymphocytes stimulated with a parasite Ag. Significant suppressive activity occurred in the baboon serum from 4-11 wk after the initial infection. Serum from animals with a chronic infection of 6-42 mo. did not suppress in vitro cell-mediated immunity. The suppressive factor was heat-stable, non-dialyzable and, following ultracentrifugation of the suppressive serum, was present in the high MW fraction. The immunosuppressive factors may be immune complexes which appear in the serum of the baboons following their infection with this blood parasite.This publication has 23 references indexed in Scilit:
- Loss of Fc receptors for IgG from human T lymphocytes exposed to IgG immune complexesNature, 1978
- Human Lymphocyte SubpopulationsPublished by Elsevier ,1978
- Effective and Ineffective Immune Responses to Parasites: Evidence from Experimental ModelsPublished by Springer Nature ,1978
- Inhibition of lymphocyte proliferation by factor(s) produced by Schistosoma mansoniEuropean Journal of Immunology, 1977
- Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of Kenyan baboons to different exposures of a local parasite strainParasitology, 1976
- The Fc receptor on thymus-derived lymphocytes. III. Mixed lymphocyte reactivity and cell-mediated lympholytic activity of Fc- and Fc+ T lymphocytes.The Journal of Experimental Medicine, 1976
- Stimulation and suppression of response of mouse T cells to the schistosomules of Schistosoma mansoni during infectionNature, 1976
- Published by Elsevier ,1976
- Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes.The Journal of Experimental Medicine, 1975