Pharmaceutical formulation optimization using sas™

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Abstract
Pharmaceutical formulation optimization consists of three distinct but Interrelated analyses, optimization, selection of key parameters and selection of key factors, all accomplished from the same set of experimental data. However, the statistical formulas and their computational algorithms are complex. Development of an In-house software Is a formidable task. Four short SAS programs are provided to accomplish the task effectively and speedily. Two optimization studies, a mobile phase composition study and a pharmaceutical formulation study are analyzed by using the programs. The contents of the output are explained clearly and interpreted appropriately.

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