Life Without Caveolae
- 28 September 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5539) , 2404-2405
- https://doi.org/10.1126/science.1065677
Abstract
Many mammalian cells have indentations in the plasma membrane called caveolae, but exactly what these flask-shaped pits do remains unclear. In a Perspective, Parton discusses the characteristics of caveolin-1-deficient mice that lack caveolae ( Drab et al.). The mice are fertile and seem healthy but show cardiovascular defects, suggesting that caveolae may be important in nitric oxide signaling and cellular proliferation.Keywords
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