ANGIOTENSIN CONVERTING ENZYME CONCENTRATIONS IN THE LUNG LAVAGE OF NORMAL RABBITS AND RABBITS TREATED WITH NITROGEN-MUSTARD EXPOSED TO HYPEROXIA

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Abstract
Increased concentrations of angiotensin converting enzyme (ACE) were found in lung lavages from rabbits exposed to hyperoxia for 72 h and concentrations of ACE were correlated with ratios of extravascular lung water to body weight (r = 0.69 P < 0.05) and albumin concentrations in lung lavages (r = 0.89, P < 0.01). Rabbits treated with nitrogen mustard in which granulocytopenia was maintained throughout the 72 h hyperoxic exposure period had less evidence of edematous lung injury and lower concentrations of ACE in lung lavages than similarly treated rabbits in which granulocytopenia was not maintained. Granulocytes contributed to acute edematous lung injury from hyperoxia and ACE concentrations in lung lavages reflected this process.