Genetic polymorphism of inter-alpha-trypsin-inhibitor (ITI): Formal genetic and linkage analyses

1 January 1991

journal article
Published by Springer Nature in Human Genetics

Vol. 87 (1) , 89-90
https://doi.org/10.1007/bf01213100

Abstract

The polymorphism of inter-alpha-trypsin-inhibitor, ITI, was demonstrated by isoelectric focusing in agarose gels (pH 5–8) followed by protein blotting and immunoassay. Segregation in 239 families with 677 children is consistent with the formal hypothesis that there are two common codominant alleles, ITI^*1, ITI^*2, and one rare codominant allele, ITI^*3, at an autosomal locus ITI. Allele frequencies were calculated as ITI^*1=0.600, ITI^*2=0.393, ITI^*3=0.007. Linkage analysis with 36 markers is presented. Slightly positive lod scores were obtained for PGM3 (z=1,35, θ=0.10) and AK1 (z=1.34, θ=0.10).

Keywords

This publication has 2 references indexed in Scilit:

A ?new? genetic polymorphism of a human serum protein: inter-alpha-trypsin-inhibitor
Human Genetics, 1990
cDNA Cloning of Human Inter-α-Trypsin Inhibitor Discloses Three Different Proteins
Biological Chemistry Hoppe-Seyler, 1987