Uracil Derivatives and Related Compounds. III. 5-Amino-1, 3, 6-trialkyluracil Derivatives. (1).

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Abstract
5-(2-Dimethylaminoacylamino)-1, 3, 6-trialkyluracils, which are analogous to Aminopropylon in chemical structure, were synthesized and their pharmacological activities were tested (Table I). Quaternary ammonium salt of these compounds with methyl bromide showed remarkable increase in their toxicity, but, generally, they showed comparatively satisfactory results both in analgesic activity and toxicity.

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