Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
Top Cited Papers
- 12 August 2004
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 351 (7) , 657-667
- https://doi.org/10.1056/nejmoa040258
Abstract
The progression of chronic myelogenous leukemia (CML) to blast crisis is supported by self-renewing leukemic stem cells. In normal mouse hematopoietic stem cells, the process of self-renewal involves the β-catenin–signaling pathway. We investigated whether leukemic stem cells in CML also use the β-catenin pathway for self-renewal.Keywords
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