Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis
- 1 December 2001
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 82 (12) , 2973-2977
- https://doi.org/10.1099/0022-1317-82-12-2973
Abstract
A serological survey for human T-lymphotropic virus (HTLV)/simian T-lymphotropic virus (STLV) antibodies was performed in 102 wild-caught monkeys and apes from 15 (sub)species originating from Cameroon. Two animals (a Mandrillus sphinx and a Cercocebus agilis) exhibited a complete HTLV-1 seroreactivity pattern while two others lacked either the p24 (a Mandrillus sphinx) or the MTA-1/gp46 bands (a Pan troglodytes). Sequence comparison and phylogenetic analyses, using a 522 bp env gene fragment and the complete LTR, indicated that the two mandrill STLV strains belonged to the HTLV/STLV subtype D clade while the chimpanzee strain clustered in the HTLV/STLV subtype B clade. The Cercocebus agilis STLV strain, the first one found in this species, was closely related to the two HTLV/STLV subtype F strains. Such data indicate that the African biodiversity of STLV-1 in the wild is far from being known and reinforces the hypothesis of interspecies transmission of STLV-1 from monkeys and apes to humans leading to the present day distribution of HTLV-1 in African inhabitants.Keywords
This publication has 31 references indexed in Scilit:
- Molecular Characterization and Phylogenetic Analyses of a New Simian T Cell Lymphotropic Virus Type 1 in a Wild-Caught African Baboon (Papio anubis) with an Indeterminate STLV Type 2-Like SerologyAIDS Research and Human Retroviruses, 2000
- Phylogenetic Analysis of Simian T Lymphotropic Virus Type I from Kenyan Olive Baboons (Papio anubis), Lowland Sykes Monkeys (Cercopithecus mitis), and Vervet Monkeys (Cercopithecus aethiops pygerythrus)AIDS Research and Human Retroviruses, 1999
- Phylogenetic Analysis of SIV and STLV Type I in Mandrills (Mandrillus sphinx): Indications That Intracolony Transmissions Are Predominantly the Result of Male-to-Male Aggressive ContactsAIDS Research and Human Retroviruses, 1998
- Sequence Variation and Subtyping of Human and Simian T-Cell Lymphotropic Virus Type I Strains from South AfricaJAIDS Journal of Acquired Immune Deficiency Syndromes, 1996
- Sequence Note: Phylogenetic Characterization of Simian T Lymphotropic Virus Type I (STLV-I) from the Ethiopian Sacred Baboon (Papio hamadryas)AIDS Research and Human Retroviruses, 1996
- Increased Risk for a Second Retroviral Infection (SIV or STLV Type I) for Wild African Green Monkeys Already Infected by One Retrovirus in Senegal (West Africa)AIDS Research and Human Retroviruses, 1995
- Serological survey and virus isolation of simian T‐cell leukemia/T‐lymphotropic virus type I (STLV‐I) in non‐human primates in their native countriesInternational Journal of Cancer, 1987
- Human T-cell leukemia virus type I is a member of the African subtype of simian viruses (STLV)Virology, 1986
- Novel Viral Sequences Related to Human T-Cell Leukemia Virus in T Cells of a Seropositive BaboonScience, 1984
- NATURAL ADULT T-CELL LEUKAEMIA VIRUS INFECTION IN JAPANESE MONKEYSThe Lancet, 1982