CROSS-PROTECTION INDUCED IN MICE BY IMMUNIZATIONS WITH PROTEINS OF RELATED BACTERIA SPECIES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 234  (1) , 46-52
Abstract
Groups of mice were immunized with detoxified proteins from Salmonella typhimurium, S. paratyphi B and S. paratyphi C. Consecutive infections with different concentrations of the homologous and heterologous strains showed the following. Immunizations with proteins from S. typhimurium induced protection in 65% of the mice infected with 50 LD100 of their natural pathogen, and in 80% of the mice infected with 50 LD100 of S. paratyphi B; the infection with S. paratyphi C in this group afforded protection against 20 LD100 in 75% of the animals. Immunization with proteins from S. paratyphi B induced protection in the mice against infection with 20 LD100 of S. typhimurium (survival of 80% of the mice) and against 20 LD100 of the homologous S. paratyphi B (survival of 90% of the mice). Immunization with proteins from S. paratyphi C protected the mice against the infection with 20 LD100 of S. typhimurium in 80-85% of the animals; infection with the homologous S. paratyphi C did not result in protection against < 20 LD100 of the bacteria (80-85% survival). All survivors in each group, when reinfected 30 days later with 50 LD100 of S. typhimurium, resisted infection as a consequence of antibodies induced against more specific proteins released in the mice during the infections by the related pathogens.

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