FAMILY STUDIES IN DERMATITIS-HERPETIFORMIS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 8  (4) , 254-261
Abstract
Six families were studied which included 11 members with dermatitis herpetiformis (DH) and 3 with coeliac disease (CD). Proximal jejunal biopsies performed on 20 relatives revealed villous atrophy in 8. Of these 8, 2, both siblings of patients with DH, had a history of juvenile CD. Determinations of histocompatibility (HLA) antigens showed that HLA-B8 occurred in all 6 families although 2 patients with DH and 1 relative with a history of juvenile CD lacked this antigen. In 1 family the haplotype A1,B8 was associated with DH, villous atrophy, juvenile diabetes and Addison''s disease. Skin biopsy failed to reveal IgA in any of the 44 relatives studied for this immunoglobulin. Antireticulin antibody was detected in the sera of 7 (17%) relatives.

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