Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrine

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Abstract
DNA fragmentation induced in the livers of rats by oral treatment with NaNO2 and aminopyrine [potential carcinogens] was evaluated by the alkaline elution technique. Whereas simultaneous administration of the 2 compounds in a single dose produced only a minimal increase of the DNA elution rate, their intake with drinking water for 20 successive days caused DNA fragmentation comparable to that observed after a single i.p. injection of 10-20 mg/kg N-nitrosodimethylamine. NaNO2 or aminopyrine alone induced borderline DNA damaging effects, if any, in rats receiving a single dose and those treated for 20 successive days.