AVIAN THYMIC ACCESSORY CELLS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 132  (4) , 1748-1755
Abstract
On the basis of morphologic criteria and ingestion of latex particles, 2 basic types of accessory cells can be identified from quail and chick thymuses, dendritic cells and macrophages. By using embryonic grafting techniques, it was shown that cells of this lineage enter the thymus during the initial colonization of the epithelial thymic rudiment by hemopoietic cells and within a few days differentiate into cells exhibiting properties of glass adherence, Ia expression and formation of rosettes with thymocytes. It appears that the precursors of this lineage undergo extensive, but finite, proliferation and are eventually replaced by further influx of the accessory cell lineage. In chimeric grafts, quail thymocytes were seen forming rosettes with chick accessory cells, and vice versa, indicating, as in the interaction between the epithelial cells and thymocytes, that the molecules involved in thymocyte-accessory cell association can interact across species barriers in the system.

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