CROSS-REACTIONS OF STREPTOCOCCAL A AND V CARBOHYDRATES IN TYPE II ANTIPNEUMOCOCCAL HORSE SERA

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Abstract
Through the use of quantitative immunochemical techniques, predictions have been confirmed that the variant group A C-substrate of hemolytic streptococci and the enzymatically degraded group A substance would precipitate more antibody from Type II antipneumococcal sera than the original group A C-substance. The findings indicate that a portion of rhamnose, at least, in the streptococcal substances is linked in the 1-3 positions, as in the rhamnose in the specific polysaccharide of Type II pneumococus. Degration of A, D, and V, by V enzyme, results in fragments which cross react only by inhibition of precipitation by the intact substances.