PI (?1-antitrypsin) subtypes: Frequency of PI*M4 in several populations
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 62 (2) , 139-141
- https://doi.org/10.1007/bf00282302
Abstract
Sera from different populations (Dutch, Northern and Southern Italians and Spaniards) were screened for PI (α1-antitrypsin) types and subtypes. A polyacrylamide isoelectric focusing method was applied, which consisted of the combined use of an ultra-thin highly cross-linked gel, restricted pH range carrier ampholytes and a separator. This technique enabled easy typing and subtyping of all known PI phenotypes including PI*M subtypes. The frequency of the new PI*M4 allele was lowest of all PI*M alleles (0.0476 in The Netherlands, 0.0371 in Northern Italy, 0.0308 in Southern Italy and 0.0146 in Spain).This publication has 23 references indexed in Scilit:
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