Progression of Parkinsonism and Loss of Cognitive Function in Alzheimer Disease
Open Access
- 1 June 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 57 (6) , 855-860
- https://doi.org/10.1001/archneur.57.6.855
Abstract
SIGNS OF parkinsonism are common in Alzheimer disease (AD), but their relation to the principal manifestation of the disease, progressive cognitive decline, has been controversial. Several cross-sectional studies have found greater cognitive impairment, on average, in persons with parkinsonian signs compared with those without them,1-10 but evidence of this association in other studies has been mixed11,12 or absent.13,14 Some longitudinal studies have found that the presence of parkinsonism at the initial evaluation, or at some other specified point, is associated with more rapid cognitive decline.10,15,16 Other longitudinal studies, however, have obtained mixed14,17 or null5,18-20 results.Keywords
This publication has 3 references indexed in Scilit:
- Problems in Measuring and Interpreting Cognitive DeclineJournal of the American Geriatrics Society, 1998
- Oxidative damage in neurodegenerative diseaseThe Lancet, 1994
- Cognitive profile of Alzheimer patients with extrapyramidal signs: A longitudinal studyJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1992