Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years
- 2 November 1994
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 272 (17) , 1335-1340
- https://doi.org/10.1001/jama.1994.03520170045034
Abstract
Objectives. —To determine whether elevated serum cholesterol level is associated with all-cause mortality, mortality from coronary heart disease, or hospitalization for acute myocardial infarction and unstable angina in persons older than 70 years. Also, to evaluate the association between low levels of high-density lipoprotein cholesterol (HDL-C) and elevated ratio of serum cholesterol to HDL-C with these outcomes. Design. —Prospective, community-based cohort study with yearly interviews. Participants. —A total of 997 subjects who were interviewed in 1988 as part of the New Haven, Conn, cohort of the Established Population for the Epidemiologic Study of the Elderly (EPESE) and consented to have blood drawn. Main Outcome Measures. —The risk factor—adjusted odds ratios of the 4-year incidence of all-cause mortality, mortality from coronary heart disease, and hospitalization for myocardial infarction or unstable angina were calculated for the following: subjects with total serum cholesterol levels greater than or equal to 6.20 mmol/L (≥240 mg/dL) compared with subjects with cholesterol levels less than 5.20 mmol/L (JAMA. 1994;272:1335-1340)Keywords
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