Granulocyte Adherence Changes Induced by Hemodialysis, Endotoxin, Epinephrine, and Glucocorticoids

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Abstract
Granulocyte [human] adherence was studied in several situations of altered granulocyte kinetics. During the transient granulocytopenia of hemodialysis, adherence increased to 481.7% of baseline by 15 min and was normal by 60 min. One h after endotoxin administration, adherence was 160.5% of control as granulocyte counts fell to 21.4%; conversely, the 24-h postdose granulocytosis was associated with a 43.0% decrease in adherence. Epinephrine produced a 25.8% decrease in adherence, with demargination granulocytosis 146.1% of control period. Alternate-day prednisone administration inhibited adherence by 38.9% on the on day, concomitant with prolonged granulocyte intravascular half-life, but adherence returned to normal on the off day when intravascular half-life is normal. In each situation, a plasma factor not present in serum was responsible for the modified adherence; if these factors produce the same adherence changes in vivo, they may be responsible for the alterations noted in granulocyte kinetics.