Interactions of aluminum, and calcium ions with nalidixic acid.

Publisher Website
Google Scholar
Abstract
Interaction of nalidixic acid with Al ion was revealed by spectrophotometric study. Stoichiometry of the nalidixic acid-Al ion complex was estimated to be 3-1 by the method of continuous variations. The interaction was further supported by an increase in solubility of the drug with increasing concentration of Al ion, by a decrease in (carbon tetrachloride/acetate buffer, pH 3.3) partition coefficient with increasing concentration of Al ion in the aqueous layer and by a decrease in the permeation rate of the drug through a cellulose membrane in the presence of Al ion in the donor compartment. Interaction of nalidixate anion with Mg and Ca ions was also shown spectrophotometrically.

This publication has 1 reference indexed in Scilit: