Hormone Replacement Therapy and Peripheral Arterial Disease

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Abstract
PERIPHERAL ARTERIAL disease (PAD) is a growing clinical and public health issue among elderly women. Prevalence rates have been estimated to range from 6% to 25% among women older than 55 years, and increase sharply with age. With the relatively large expected increase in the number of elderly women compared with elderly men, women will make up most of the patients with PAD in the next century. Several studies have demonstrated that patients with PAD, with or without complaints of intermittent claudication, are at an increased risk of cardiovascular morbidity and mortality compared with people without PAD.1