Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing.
- 1 July 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (13) , 4894-4897
- https://doi.org/10.1073/pnas.85.13.4894
Abstract
An important event during wound healing is the contraction of newly formed connective tissue (granulation tissue) by fibroblasts. The role of polypeptide growth factors in the process of wound contraction was investigated by analyzing the influence of transforming growth factor .beta. (TGF-.beta.), platelet-derived growth factor, fibroblast growth factor, and epidermal growth on the ability of fibroblasts to contract a collagen matrix in an in vitro system. TGF-.beta., but not the other growth factors tested, markedly enhanced the ability of BHK-21, 3T3-L1, and human foreskin fibroblasts to contract collagen gels. These results suggest that TGF-.beta. released from platelets and inflammatory cells at sites of tissue injury stimulates fibroblasts to contract the provisional wound matrix and that this effect contributes to the ability of TGF-.beta. to accelerate wound healing.This publication has 28 references indexed in Scilit:
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