Cytoprotective Effect of SU-88, an Anti-Ulcer Agent, in the Rat

Open Access
Publisher Website
Google Scholar
Abstract
The gastric cytoprotective action of SU-88, an anti-ulcer agent, was studied in rats. SU-88 dose-dependently prevented the formation of gastric lesions induced by absolute ethanol as observed by PGE2 [prostaglandin E2]. The efficacy of SU-88 when given i.p. was more potent than the p.o. [oral] administration. Indomethacin (5 mg/kg, p.o.) given 30 min prior to SU-88 dosing, blocked this protective effect, whereas it was not affected when indomethacin was given 30 min after the SU-88 dosing. Cimetidine failed to exert a protective effect against the ethanol-induced lesions and caused a significant increase in the lesions induced by 0.6 N HCl. Pretreatment with SU-88 prior to cimetidine resulted in a marked reduction in the lesions. SU-88 increased the synthesis of gastric glycoproteins and prevented the reduction of glycoprotein synthesis caused by the administration of absolute ethanol. No increase in the synthesis was observed 5 min after the SU-88 dosing, although the lesion was significantly suppressed at that time. SU-88 evidently possesses a cytoprotective effect and this effect seems to be mediated by the increase in endogenous PG.