CYANIDE ANTIDOTES

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Abstract
Successful chemical antidotes in the treatment of experimental cyanide poisoning are methylene blue, sodium nitrite, triose and sodium thiosulphate. Within limitations, all these agents, except triose, which has not been tried in man, have a demonstrated clinical usefulness. Their actions are both protective and resuscitative. Differing as they do chemically and physically, these agents might also be expected to mediate their antidotal actions differently. This is probably true for simple physical and biologic systems, but in mammals matters appear to be different, and even among different mammals. For instance, in some species (dogs) methylene blue and sodium nitrite are reported to act through the same mechanism which does not seem to be invoked in others (rabbits). Triose and thiosulphate appear to act differently from the dye and nitrite. The newer concepts and apparent complications in these antidotes ought to be understood and explained, if possible, for a proper appreciation and

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