Effects of Vitamin E on Mixed Lymphocyte Cultures

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Abstract
When lymphocytes from [human] individuals ingesting vitamin E were used as responding cells in the mixed lymphocyte culture (MLC) the proliferative response was normal, indicating that T lymphocyte reactivity to allogeneic antigen was undisturbed. The use of lymphocytes from individuals receiving vitamin E as stimulating cells in the MLC resulted in a diminished proliferative response, suggesting that large doses of vitamin E may effect B cells and/or macrophages as they interacted with T lymphocytes.