Anatomic, Metabolic, Neuropsychological, and Molecular Genetic Studies of Three Pairs of Identical Twins Discordant for Dementia of the Alzheimer's Type
- 1 February 1991
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 48 (2) , 160-168
- https://doi.org/10.1001/archneur.1991.00530140052017
Abstract
• Three pairs of twins, each with proved monozygosity, were shown to be discordant for dementia of the Alzheimer's type and to have remained discordant for periods of 8 to 11 years. Dementia of the Alzheimer's type was demonstrated by history; serial clinical examinations; serial measurements of cerebral glucose utilization using positron emission tomography and of cerebral ventricular volumes and of rates of change of volumes using quantitative computed tomography; and by serial neuropsychological tests. The results of each of these measures showed no evidence of clinical abnormality in any unaffected twin. DNA markers from the proximal long arm of chromosome 21 did not distinguish between the affected and the unaffected member of any pair of identical twins. Family pedigrees were negative for Alzheimer's disease. The results suggest that environmental or other nongenetic factors contribute to Alzheimer's disease in discordant monozygotic twins, or that some cases arise by a postzygotic somatic mutation.Keywords
This publication has 12 references indexed in Scilit:
- Monozygotic twins concordant for probable Alzheimer disease and increased platelet membrane fluidityAmerican Journal of Medical Genetics, 1988
- Rate of ventricular enlargement in dementia of the Alzheimer type correlates with rate of neuropsychological deteriorationNeurology, 1987
- Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer typeNeurology, 1986
- Identical Twins Discordant for Presenile Dementia of the Alzheimer TypeThe British Journal of Psychiatry, 1986
- Familial Alzheimer Dementia: a prevalent disorder with specific clinical featuresPsychological Medicine, 1984
- Genetic components and intellectual functioning during senescence: A 20-year study of aging twinsBehavior Genetics, 1972
- The Morbidity Rate and Environmental Influence in Monozygotic Co-twins of SchizophrenicsThe British Journal of Psychiatry, 1969
- Old wine in new skins: Grouping Wechsler subtests into new scales.Journal of Consulting Psychology, 1967
- Intellectual Changes in Aged TwinsJournal of Gerontology, 1962
- A Standardized Memory Scale for Clinical UseThe Journal of Psychology, 1945