PITUITARY GRAFTS AND MILK SECRETION IN HYPOPHYSECTOMIZED RATS

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Abstract
SUMMARY Lactating rats were implanted under the kidney capsule or in the anterior chamber of the eye with pituitary tissue obtained from their 7–8-day-old sucklings. These rats were again mated and were hypophysectomized on the 4th day of their second lactation. Injections of oxytocin were given thrice daily to induce milk ejection. In such rats the pituitary grafts under the kidney capsule gave a slight temporary maintenance of milk secretion. Substantial increases in the amount of milk and in the duration of milk secretion were obtained when the grafted animals were given daily injections of adrenocorticotrophin. The administration of antidiuretic hormone failed to increase significantly the milk yield of grafted animals. These observations are consistent with the view that such pituitary grafts secrete prolactin.

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