Oxidative injury and survival during endotoxemia

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Abstract
This study investigates the plasma levels of 8‐iso‐PGF2α, a non‐enzymatic, and 15‐K‐DH‐PGF2α, a cyclooxygenase catalyzed oxidation product of arachidonic acid in an experimental porcine endotoxemic shock model. A significant (P2α metabolite after endotoxin infusion was very similar in both non‐survival and survival groups indicating an acute progression and recession of inflammation. When oxidative injury was assessed by measuring free 8‐iso‐PGF2α the levels in plasma increased significantly up to 2 h and remained at this level until death among the non‐survivors. This was apparently different from the survivors where the 8‐iso‐PGF2α levels increased to its height at 1 h, then decreased to the basal levels after 5 h. Thus, free radical and cyclooxygenase catalyzed oxidation of arachidonic acid occurs during endotoxemia. Free radical dependent oxidative injury following endotoxin induced inflammation may be the major cause of organ failure and increased mortality.