Seasonal variation in bone metabolism in young healthy subjects
- 1 March 1991
- journal article
- clinical trial
- Published by Springer Nature in Calcified Tissue International
- Vol. 49 (2) , 84-89
- https://doi.org/10.1007/bf02565126
Abstract
Serum vitamin D metabolites and urinary calcium excretion; parameters of bone formation (serum alkaline phosphatase, serum osteocalcin); parameters of bone resorption (24 hour hydroxyprolinuria, 2 hour fasting urinary hydroxyproline/creatinine ratio); and parameters of cortical and trabecular bone density, parathyroid hormone (iPTH, COOH terminal assay), and serum minerals (calcium, phosphorus) were followed serially in 55 young adults (21 women and 34 men) from December 1985 until January 1987 at four different times during the year. The effect of a low-dose cyclooxygenase inhibitor (piroxicam 5 mg daily) on the same parameters of bone density and bone turnover when given from December until May, was also evaluated in this study. At the end of the treatment period parameters of bone turnover and bone density were comparable between placebo and piroxicam-treated groups. Therefore, the results of all subjects were pooled in order to investigate seasonal variation. In both sexes, seasonal variation was found not only for 250HD3 but also for 1,25(OH)2D3, serum calcium and phosphorus, urinary calcium excretion, and for bone density at the lumbar spine. Parameters of bone formation (serum osteocalcin and alkaline phosphatase), bone resorption (24 hour urinary hydroxyprolinuria and fasting urinary hydroxyproline/creatinine ratio) and PTH were influenced by this seasonal variation. We conclude that in young adults, a significant seasonal variation occurs, with low winter and high summer values, for serum 25 and 1,25(OH)2D3 for urinary calcium apparently without important influence on parameters of bone turnover or parathyroid activity and for lumbar spine density. Treatment with a low-dose cyclooxygenase inhibitor was without influence on the observed changes.Keywords
This publication has 37 references indexed in Scilit:
- Local and Systemic Factors in the Pathogenesis of OsteoporosisNew England Journal of Medicine, 1988
- Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older ratsBone, 1988
- Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man.Journal of Clinical Investigation, 1984
- Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoidsMetabolic Bone Disease and Related Research, 1984
- Vitamin D metabolites in normal subjects during one year. A longitudinal studyScandinavian Journal of Clinical and Laboratory Investigation, 1983
- SEASONAL VARIATION IN SERUM-25-HYDROXYVITAMIN-D IN THE ELDERLY IN BRITAINThe Lancet, 1977
- SUNLIGHT AND HYPERCALCIURIAThe Lancet, 1975
- Seasonal Variations in Urinary Excretion of CalciumBMJ, 1974
- Seasonal Changes in Human Plasma Levels of 25-Hydroxyvitamin DNature, 1974
- Seasonal Variations in Bone Mineral Content after the MenopauseNature, 1973