On the Survival of the Completely Depancreatized Dog

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Abstract
When maintained with insulin and a high-calorie, high-protein, high-vitamin diet, completely depancreatized dogs may survive for as long as 4 to 5 years. The pathological changes observed in these animals during survival are recorded. This length of survival makes it unnecessary to assume that raw pancreas or extracts thereof or choline supplements (i.e., in addition to that contained in the dietary constitutents) are essential for the survival of the completely depancreatized dog receiving insulin. The previous failures to obtain lengthy survival of completely depancreatized dogs maintained with insulin and a diet containing no pancreas are examined and shown to be of questionable significance in view of the inadequate diets employed.
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