The Relation between Panthothenic Acid and Plasmodium gallinaceum Infections in the Chicken and the Antimalarial Activity of Analogues of Pantothenic Acid

Publisher Website
Google Scholar
Abstract
Blood- but not sporozoite-induced infections of P. gallinaceum are suppressed in pantothenic-acid-deficient chickens or in chickens treated orally with analogues of pantothenic acid. This suggests that the blood phases of this infection require pantothenic acid. The tissue phases may either not require the vitamin or find sufficient quantities in the tissues of chickens even when they are fed deficient diets or are treated with analogues of the vitamin. Pantoyltaurine and 17 derivatives of pantoyl-tauramide, analogues of pantothenic acid, were tested for antimalarial activity. The drugs, except pantoyltaurine, were administered as an ingredient of the diet. The most active member of the series, pantoyltauramido-4-chloro-benzene, is 4 times as active as quinine in a standard 4-day blood-induced infection and is 16 times as active in a more sensitive test. Several of the compounds were administered as single oral daily doses and were active, but 2-3 times as much drug is required as when administered in the diet. The suppressive action of the drugs is completely antagonized by addition of pantothenic acid to the drug-containing diet. The spread between the therapeutic and the toxic doses of pantoyltauramido-4-chlorobenzene is about 100-fold.

This publication has 3 references indexed in Scilit: