The impact of phase I clinical trials on the quality of life of patients with cancer
- 1 December 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 3 (6) , 571-576
- https://doi.org/10.1097/00001813-199212000-00003
Abstract
This prospective, non-randomized study was designed to evaluate the quality of life (QOL) of cancer patients receiving new cytoxic therapy. QOL was measured using a linear analog self assessment scale (LASA). Cancer patients who received a phase I agent (n = 45) had no significant changes in any of the Individual QOL variables, overall QOL (p = 0.77) or performance status (p = 0.08) following one course of phase I therapy. However, patients who were not eligible for entry on a phase I protocol and who received supportive care (n = 10) experienced significant decreases in overall QOL (p = 0.02) and performance status (p = 0.003) after 1 month of follow-up. This pilot study suggests that participation in phase I trials does not adversely affect one's QOL.Keywords
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