Splitting of human thyroglobulin. II. Enzymatic digestion.
- 1 September 1969
- journal article
- Vol. 5 (3) , 285-97
Abstract
The antigenic mosaic of human thyroglobulin was studied following proteolysis by papain, pepsin, trypsin and chymotrypsin. Undigested thyroglobulin (Tg) was removed from the enzyme-derived fragments by gel filtration. The fragments produced by the action of trypsin precipitated with rabbit heteroantibody to thyroglobulin but failed to precipitate when tested with human autoantibody to thyroglobulin. They only weakly inhibited the tanned cell haemagglutination reaction using either human or rabbit antiserum and failed to elicit antibody following injection with Freund's adjuvant into rabbits.This publication has 7 references indexed in Scilit:
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