CURE OF CRYPTOCOCCAL INFECTION DURING CONTINUED IMMUNOSUPPRESSIVE THERAPY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 55  (217) , 169-172
Abstract
Cryptococcus neoformans is a significant pathogen in immunosuppressed patients. In renal transplant recipients receiving prednisone, the development of cryptococcosis is associated with a poor prognosis. When such patients develop cryptococcosis they pose a particularly difficult clinical dilemma since withdrawal of prednisone, to facilitate cure of their fungal infection, may predipose to loss of their transplanted kidney. Experience with cryptococcal infection in 13 renal transplant patients is reported. In 11 of these patients maintenance immunosuppression was cautiously continued to preserve allograft function. Maintenance immunosuppressive therapy apparently may be continued throughout the period of antifungal therapy and does not preclude eradication of the infecting organisms. The prognosis for the renal transplant patient who has cryptococcosis can evidently be improved.

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