Origin and Biologic Individuality of the Genetic Dictionary
- 21 December 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 138 (3547) , 1328-1331
- https://doi.org/10.1126/science.138.3547.1328
Abstract
Deoxyribonucleic acid contains sequences complementary to homologous amino-acid transfer ribonucleic acid molecules which serve as the translating device between polyribonucleotides and proteins. This implies that the RNA molecules have their primary origin in DNA. From the amount of DNA participating, one would infer that more than 20 complementary sequences exist per genome, a conclusion consistent with a degenerate code. The fact that complex formation occurs most readily with homologous RNA suggests that, while the language remains universal, each dictionary is uniquely identifiable with its own genome.Keywords
This publication has 8 references indexed in Scilit:
- Homology Test between the Nucleic Acid of an RNA Virus and the DNA in the Host CellScience, 1962
- POLYURIDYLIC ACID STIMULATION OF PHENYLALANINE INCORPORATION IN ANIMAL CELL EXTRACTSProceedings of the National Academy of Sciences, 1962
- Non-random base sequence of S-RNA and an hypothesis for S-RNA biosynthesisJournal of Molecular Biology, 1962
- THE IDENTIFICATION OF THE RIBOSOMAL RNA CISTRON BY SEQUENCE COMPLEMENTARITY, I SPECIFICITY OF COMPLEX FORMATIONProceedings of the National Academy of Sciences, 1962
- Determination of the Helical Configuration of Ribonucleic Acid Molecules by X-Ray Diffraction Study of Crystalline Amino-Acid–transfer Ribonucleic AcidNature, 1962
- AN INTERMEDIATE IN THE BIOSYNTHESIS OF POLYPHENYLALANINE DIRECTED BY SYNTHETIC TEMPLATE RNAProceedings of the National Academy of Sciences, 1962
- A fractionating column for analysis of nucleic acidsAnalytical Biochemistry, 1960
- Infectivity of Ribonucleic Acid from Tobacco Mosaic VirusNature, 1956