A Saporin‐6 cDNA containing a precursor sequence coding for a carboxyl‐terminal extension
- 21 October 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 291 (2) , 285-288
- https://doi.org/10.1016/0014-5793(91)81303-p
Abstract
Saporin-6 is a single-chain ribosome inactivating protein (RIP) from the seeds and the leaves of Saponaria officinalis (Caryophyllaceae). Here we have identified the COOH-terminal end of mature Saporin-6 and, by cDNA sequencing, the predicted carboxyl-terminal sequence of a leaf saporin-6 primary translation product. Our data indicate that the characterized cDNA codes for a precursor contiaing a 22 amino acid carboxyl-terminal extension, not present in mature Saporin-6, that shows similarity to carboxyl-terminal propeptides of vacuolar proteins, suggesting that it may be involved in protein trafficking.Keywords
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