Clinical Features and Contribution of Virological Findings to the Management of Kaposi Sarcoma in Organ-Allograft Recipients

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Abstract
HUMAN herpesvirus 8 (HHV-8), also known as Kaposi sarcoma (KS)–associated herpesvirus,1 is associated with 3 diseases: KS, primary effusion lymphoma, and some forms of multicentric Castleman disease.2 Since HHV-8 is considered the etiological agent of all clinical types of KS, virological and immunological analyses, such as detection of HHV-8 DNA in different tissue samples or anti–HHV-8 antibodies in serum samples and classification of HHV-8 subtypes, are now available. The aims of this study were to describe the clinical features and evolution of KS in a series of organ-allograft recipients and to determine the contribution of these HHV-8 investigations to patient management.