1-Oxidopyridin-2-yldiazomethane: a water-soluble alkylating agent for nucleosides and nucleotides
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 673-674
- https://doi.org/10.1039/c39730000673
Abstract
The water-soluble alkylating agent: 1-oxido-pyridin-2-yldiazomethane (I) introduces the 1-oxido-pyridin-2-ylmethyl protecting group into acidic substances (pKa < 9·8) including nucleotides; it can be removed by treatment with acetic anhydride followed by methanolic ammonia.Keywords
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