Renal Tubular Acidosis

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Abstract
Several kinds of tubular dysfunction can underlie renal tubular acidosis (RTA), a syndrome of disordered renal acidification that causes metabolic acidosis without (or with only a moderate) reduction in renal mass. Slowly developing and painfully disabling osteomalacia was once the major metabolic consequence of untreated RTA of the physiologic type first investigated in detail1 — now termed Type 1 or "classic" RTA (RTA-1) — and characterized by an inappropriately high urinary pH during severe as well as mild acidosis.2 But nowadays in the United States, the hyperchloremic acidosis that characterizes all physiologic subtypes of RTA is so readily detected, and . . .