Acetylcholinesterase and Glucose-6-Phosphate Dehydrogenase Activities in Erythrocytes of Fetal, Newborn and Adult Sheep.

Abstract
The activity of the stromal enzyme acetylcholinesterase (ACHE) was similar in fetal, newborn and adult sheep erythrocytes. Ovine red cell ACHE activity was 25% that of cells from adult humans. The activity of glucose-6-phosphate dehydrogenase (G6PD), a cytoplasmic enzyme, was 3 times higher in fetal and newborn erythrocytes than in cells of adult sheep. G6PD activity of erythrocytes from adult animals was 1/5 that of cells from normal human adults. Segregation of ovine erythrocytes into young and aged cell populations was done microgravimetrically. The activity of both enzymes was higher in younger cells than in older erythrocytes of the 3 groups of animals studied.

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