Antibacterial activity of the new carbapenem meropenem (SM-7338) against clinical isolates
- 1 December 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 8 (12) , 1053-1061
- https://doi.org/10.1007/bf01975169
Abstract
The in vitro antibacterial activity of the new carbapenem antibiotic meropenem (SM-7338) against 567 clinical isolates was evaluated. SM-7338 exhibited activity against a broad spectrum of organisms, including aerobes and anaerobes, and was superior to the other beta-lactam drugs tested (piperacillin, cefotaxime, ceftazidime, ceftriaxone, cefoxitin). SM-7338 was more active than imipenem, gentamicin and amikacin againstEnterobacter cloacae andPseudomonas aeruginosa. SM-7338 was less potent than imipenem against staphylococci and enterococci, but the activity of the two antibiotics against anaerobes was similar. SM-7338 and imipenem showed a high bactericidal activity at a concentration of 2–4 x MIC.Keywords
This publication has 1 reference indexed in Scilit:
- In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase IAntimicrobial Agents and Chemotherapy, 1989