Stereoselective Synthesis of (+)-Swainsonine and (-)-8,8a-Di-epi-swainsonine
- 1 May 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (05) , 404-406
- https://doi.org/10.1055/s-1995-5002
Abstract
(+)-Swainsonine 2 and (-)-8,8a-di-epi-swainsonine 3 were stereoselectively synthesized from L-glutamic acid via a highly diastereoselective intramolecular conjugate addition of amide 20 and carbamate 8, respectively. Another key step is a stereoselective osmium-catalyzed dihydroxylation of indolizidine double bond.Keywords
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