Relationship of the Pituitary to the x zone of the Mouse Adrenal.

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Abstract
Virgin female mice, 40-42 days of age when the X zone is well developed, were hypophysectomized. 14 days later the X zone was still present but had condensed with the nuclei pycnotic and the cell cytoplasm shrunken with loss of typical eosinophilia. Those mice injected with LH had the X zone well maintained, the rest of the cortex being unaffected by the injns. and showed the changes concomitant with hypophysectomy. Mice injected with FSH showed only slight maintenance of the X zone and this probably due to the contaminating LH in the prepn. Mice injected with ACTH showed no maintenance of the X zone, but the rest of the cortex was well sustained. Mice injected with human chor-ionic gonadotropin had no X zone and a medullary connective tissue capsule had formed. It seems then that the X zone is dependent on a pituitary gonadotropin for its maintenance and growth in the normal animal, and it is probably LH which is the maintaining factor.