RAT THYROTROPHIN LEVELS DURING HEAT STRESS AND STIMULATION BY THYROTROPHIN RELEASING FACTOR

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Abstract
The negative feedback action of the hypothalamic—hypophysial—thyroid system is abolished in rats kept at 37 °C, presumably due to the stress of the high temperature (Weller, Dikstein & Sulman 1969; Tal & Sulman, 1971). The present investigation compares pituitary thyroid-stimulating hormone (TSH) levels in rats kept at room temperature (23 °C) or at higher temperatures (34 °C or 37 °C). Six groups of 12 male albino rats of the Hebrew University Sabra strain, 42 days old and weighing 120 ± 5 g each, were housed six to a cage in three rooms at 23 ± 1 °C, 34 ± 1 °C and 37 ± 1 °C respectively. The rats received standard laboratory pellets and water ad libitum. Synthetic thyrotrophin releasing factor (TRF) (300 ng/kg body wt) (pyroglutamyl-histidyl-prolinamide, Farbwerke Hoechst A.G., Frankfurt) was injected i.v. (Kendall, Rees & Kramer, 1971) on the 4th day in the experimental groups. The rats were

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