SPREAD OF ACh INDUCED ELECTRICAL DISCHARGES OF THE CEREBRAL CORTEX

Publisher Website
Google Scholar
Abstract
The topical applications of acetylcholine (ACh) to the exposed cerebral cortex of the cat produces a high voltage spiking discharge. These ACh discharges tend to remain localized to the area of application. Occasionally they spread spontaneously and this spread is along neuronal pathways as demonstrated by subsequent strychninization of the area of ACh application. If spread does not occur spontaneously it may be induced by strychninization of the cortex prior to treatment with ACh. Interruption of anatomical pathways, such as the corpus callosum, prevents spread of the discharge along the anatomical pathway. There is some evidence to indicate that the secondary Ach discharge is neuronal rather than axonal.

This publication has 0 references indexed in Scilit: