The Impairment of Thermoregulation by Trauma during the First Days of Life of the Rabbit

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Abstract
During the first 10–11 days of life of the rabbit there was a significant increase in the ‘minimal observed’ O2 consumption measured in a thermoneutral environment. At the appropriate thermoneutral environmental temperature an LD50 period of bilateral hind-limb ischaemia had no effect on the O2 consumption of 1-, 5- to 6-, 10- to 11- and 21- to 25-day-old rabbits until shortly before death. 1 h after a 3 hour-period of bilateral hind-limb ischaemia in a thermoneutral environment the metabolic response of the 1- to 2-day-old rabbits to cold exposure was impaired. In the uninjured 1- to 2-day-old rabbits, the summit metabolic rate was recorded at an ambient temperature of 20°C giving a metabolic quotient of 3.5, whereas in the injured (LD80) 1- to 2-day-old rabbits the summit metabolic rate was recorded at 27°C with a metabolic quotient of 2.1. The results are discussed with special reference to the effects trauma may have on the thermoregulatory role of brown adipose tissue in the newborn rabbit.

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