Adenosine deaminase polymorphism in man
- 1 July 1968
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 32 (1) , 9-14
- https://doi.org/10.1111/j.1469-1809.1968.tb00044.x
Abstract
Summary: A new and specific method for the study of adenosine deaminase isozymes is described. Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. Family studies indicate that these phenotypes are determined by two alleles, ADA1 and ADA2 at an autosomal locus. Preliminary population data suggest that ADA2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules.Keywords
This publication has 5 references indexed in Scilit:
- Multiple forms of calf serum adenosine deaminaseArchives of Biochemistry and Biophysics, 1967
- A study of the tissue distribution of adenosine deaminase in six mammal speciesComparative Biochemistry and Physiology, 1965
- A purification of adenosine deaminase from the superficial mucosa of calf intestineBiochimica et Biophysica Acta, 1962
- Adenosine deaminaseBiochemical Journal, 1942
- The deaminases of adenosine and adenylic acid in blood and tissuesBiochemical Journal, 1939