Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion Possibly Related to Advanced Age

Publisher Website
Google Scholar
Abstract
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) as a cause of hypotonic hyponatremia is well recognized. The syndrome is commonly associated with cranial and thoracic infectious disease or malignancy. An idiopathic form of the syndrome was reported, but poorly documented. The patient, an 88-yr-old man without any associated disease, had SIADH confirmed by a standard water load test. The pattern of antidiuretic hormone release corresponded to the vasopressin leak pattern. A review of 10 cases of idiopathic SIADH showed that each of these cases was associated with neuropsychiatric or other medical disturbances. Idiopathic inappropriate antidiuresis evidently exists and is a discrete category of SIADH. Advanced age may be a risk factor for this disease. This syndrome may account for the increased susceptibility to hyponatremia among older patients.