Long-Term Evaluation of Single versus Multiple Courses of Actinomycin D Therapy of Wilms's Tumor

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Abstract
Long-term analysis of the value of a single course (36 patients) versus multiple courses (37 patients) of actinomycin D in the treatment of Wilms's tumor showed that the relapse rate was significantly less in subjects given multiple-course chemotherapy. There was no significant difference in long-term survival between the two groups. Multiple courses appeared to suppress pulmonary metastases. Because of fewer relapses, fewer additional control measures were needed, and morbidity from the disease and its treatment was therefore lessened. Multiple-course therapy is preferred to a single course in Wilms's tumor. (N Engl J Med 290:84–86, 1974)

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